| 货号 | 10704-1mg |
| 描述 | (±)13-HpODE is a racemic mixture of hydroperoxides derived non-enzymatically from linoleic acid through the action of reactive oxygen species. Lipid hydroperoxides, including 13-HpODE, have limited direct biological actions, such as the activation of lipoxygenases.1 Normally, (±)13-HpODE is rapidly reduced to (±)13-HODE, a compound which exhibits many biological activities.2 Importantly, 13-HpODE can also be metabolized to unsaturated aldehydes that can, in turn, covalently bind to DNA, amino acids, and proteins.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jones, G.D.,Russell, L.,Darley-Usmar, V.M., et al. Role of lipid hydroperoxides in the activation of 15-lipoxygenase. Biochemistry 35, 7197-7203 (1996). 2.Kühn, H. Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)xy-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)xy-9Z,11E-octadecadienoic acid. Progress in Lipid Research 35, 203-226 (1996). 3.Williams, M.V.,Wishnok, J.S. and Tannenbaum, S.R. Covalent adducts arising from the decomposition products lipid hydroperoxides in the presence of cytochrome C. Chemical Research in Toxicology 20(5), 767-775 (2007). 4.Iwahashi, H.,Nishizaki, K. and Takagi, I. Cytochrome c catalyzes the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. Biochemistry Journal 361, 57-66 (2002). 5.Kawai, Y.,Kato, Y.,Fujii, H., et al. Immunochemical detection of a novel lysine adduct using an antibody to linoleic acid hydroperoxide-modifies protein. Journal of Lipid Research 44, 1124-1131 (2003). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 312.4 |
| 分子式 | C18H32O4 |
| CAS号 | 23017-93-8 |
| 稳定性 | ≥ 1 year |
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