| 货号 | 16999-50mg |
| 描述 | MEK5, also known as MAP2K5, phosphorylates ERK5 (MAPK7) in signaling pathways involved in stress-induced apoptosis, neuronal survival, cardiac development, and angiogenesis.1,2 BIX02189 is a potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively), preventing transcriptional activation of the downstream target MEF2C.3 It minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2.3 BIX02189 blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation of ERK1/2, in HeLa cells.3 It has been used to investigate the roles of MEK5/ERK5 signaling in nerve growth factor-mediated neurite outgrowth and myeloid cell differentiation.2,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wang, Y. Mitogen-activated protein kinases in heart development and diseases. Circulation 116, 1413-1423 (2007). 2.Obara, Y., and Nakahata, N. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Molecular Pharmacology 77(1), 10-16 (2010). 3.Tatake, R.J.,ONeill, M.M.,Kennedy, C.A., et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochemical and Biophysical Research Communications 377(1), 120-125 (2008). 4.Wang, X.,Pesakhov, S.,Weng, A., et al. ERK 5/MAPK pathway has a major role in 1a,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells. Journal of Steroid Biochemistry and Molecular Biology 144, 223-227 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 440.5 |
| 分子式 | C27H28N4O2 |
| CAS号 | 1265916-41-3 |
| 稳定性 | ≥ 2 years |
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