N-Acetyl-4-benzoquinone imine
货号：
16115-5mg 基本售价：
10640.0 元 规格：
5 mg
产品信息
概述| 货号 | 16115-5mg |
| 描述 | N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses.1 At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.1 |
| 别名 | NAPQI;N-Acetyl-p-benzoquinonimine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Qiu, Y.,Benet, L.Z. and Burlingame, A.L. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in Vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. The Journal of Biological Chemisty 273, 17940-17953 (1998).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 149.2 |
| 分子式 | C8H7NO2 |
| CAS号 | 50700-49-7 |
| 稳定性 | ≥ 2 years |
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