| 货号 | 5995/50 |
| 别名 | N-[4-[[6-[4-(Trifluoromethyl)phenyl |
| 供应商 | Tocris |
| 生物活性 | Potent TRPV1 antagonist (IC50 = 0.9 nM). Inhibits capsaican-induced flinching and reverses analgesia in an inflammatory pain model in rats. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 430.41 |
| 分子式 | C20H13F3N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Dohertyet al (2007) Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. J.Med.Chem. 50 3515. PMID: 17585750. Gavvaet al (2007) Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J.Pharmacol.Exp.Ther. 323 128. PMID: 17652633. Wanget al (2007) Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J.Med.Chem. 50 3528. PMID: 17585751. |