| 货号 | 4404/50 |
| 别名 | 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(tr |
| 供应商 | Tocris |
| 生物活性 | Selective positive allosteric modulator of M5(EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4receptors). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 397.35 |
| 分子式 | C22H14F3NO3< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| 参考文献 | Bridgeset al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M5 PAM. Bioorg.Med.Chem.Lett. 20 558. PMID: 20004578. Bridgeset al (2010) Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg.Med.Chem.Lett. 20 5617. PMID: 20801651. |