| 货号 | 4295/50 |
| 别名 | 4-[[2-[(2-Methylbenzoyl)amino]ethyl |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 369.89 |
| 分子式 | C18H27N3O3 |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 5 mM in DMSO |
| 参考文献 | Bridgeset al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg.Med.Chem.Lett. 20 1972. PMID: 20156687. Leboiset al (2010) Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system. ACS Chem.Neurosci. 1104. |