VU 0285683 (50 MG)
货号：
4381/50 基本售价：
10549.0 元 规格：
50 mg
产品信息
概述| 货号 | 4381/50 |
| 别名 | 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile |
性能| 供应商 | Tocris |
| 生物活性 | Negative allosteric modulator of mGlu5 receptors. Displays high affinity for the MPEP (Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu5(IC50 = 24.4 nM). Selective for mGlu5 over mGlu1, mGlu3 and mGlu4. Exhibits anxiolytic activity in rodent models of anxiety. Analog available (Cat. No. 4323). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 266.23 |
| 分子式 | C14H7FN4O |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Rodriguez (2010) Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 78 (6) 1105. PMID: 20923853. |
