| 货号 | 4233/50 |
| 别名 | 3a,4,5,9b-Tetrahydro-4-(1-naphthale |
| 供应商 | Tocris |
| 生物活性 | Type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Displays no agonist activity at α7 receptors at concentrations up to 0.1 mM; potentiates agonist-evoked responses and reduces rate of desensitization of α7 nAChRs. Exhibits potency and efficacy similar to PNU 120596 (Cat. No. 2498). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 376.47 |
| 分子式 | C22H20N2O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Gillet al (2011) Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci. 1085867. Gronlienet al (2007) Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715. PMID: 17565004. |