| 货号 | 4270/50 |
| 别名 | N1-(2-Aminophenyl)-N7-(4-methylphen |
| 供应商 | Tocris |
| 生物活性 | Class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 339.43 |
| 分子式 | C20H25N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Xuet al (2009) Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing. Chem.Biol. 16 980. PMID: 19778726. Chouet al (2008) Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J.Biol.Chem. 283 35402. PMID: 18953021. Raiet al (2008) HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS ONE 3 e1958. PMID: 18463734. |