| 货号 | 4426/50 |
| 别名 | 6,7,8,9-Tetrahydro-1,6,6-trimethylp |
| 供应商 | Tocris |
| 生物活性 | Major tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 294.34 |
| 分子式 | C19H18O3 |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO with gentle warming |
| 参考文献 | Donget al (2012) Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Mol.Biol.Rep. 39 6495. PMID: 22314911. Jinet al (2008) Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104 15. PMID: 17979138. Leeet al (2008) Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 7 3527. PMID: 19001436. Wanget al (2007) Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 82 11. PMID: 16955220. |