| 货号 | 4509/50 |
| 别名 | N-[(2-Hydroxy-1-naphthalenyl)methyl |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 317.38 |
| 分子式 | C15H11NO3S2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Kraskiewicz and FitzGerald (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 33 53. PMID: 22112465. Papandreouet al (2011) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 117 1311. PMID: 21081713. |