| 货号 | 4337/50 |
| 别名 | 5-Chloro-3-[2-(dimethylamino)ethyl] |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective agonist of 5-HT6 receptors (Ki values are 13, 168, and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors respectively). Displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM). Shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 326.78 |
| 分子式 | C13H17ClN2.C |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Riccioniet al (2011) ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned 5-HT6 receptors. Eur.J.Pharmacol. 661 8. PMID: 21549693. Valentiniet al (2011) A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology 60 602. PMID: 21185318. |