| 货号 | 4801/50 |
| 别名 | 4-[6-Methoxy-2-[(1E)-2-(3-nitrophen |
| 供应商 | Tocris |
| 生物活性 | NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 443.41 |
| 分子式 | C24H17N3O6 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| 参考文献 | Hansen and Traynelis (2011) Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 31 3650. PMID: 21389220. Mosleyet al (2010) Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J.Med.Chem. 53 5476. PMID: 20684595. |