| 货号 | 1426/50 |
| 别名 | 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5 |
| 供应商 | Tocris |
| 生物活性 | Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERα over ERβ. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 386.45 |
| 分子式 | C24H22N2O3 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 263717-53-9 |
| 参考文献 | Harriset al (2002) Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand. Endocrinology 143 4172. PMID: 12399409. Kraichelyet al (2000) Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 141 3534. PMID: 11014206. Staufferet al (2000) Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J.Med.Chem. 43 4934. PMID: 11150164. |