| 货号 | 4326/50 |
| 别名 | 9-Ethyl-N-methyl-9H-carbazole-3-met |
| 供应商 | Tocris |
| 生物活性 | p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 274.79 |
| 分子式 | C16H18N2.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| 参考文献 | Wiman (2010) Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 29 4245. PMID: 20498645. Boeckleret al (2008) Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 105 10360. PMID: 18650397. |