NAV 26 (50 MG)
货号：
4691/50 基本售价：
10549.0 元 规格：
50 mg
产品信息
概述| 货号 | 4691/50 |
| 别名 | 2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ,α,γ,β, and mTOR, respectively). Displays no significant inhibitory activity at more than 80 protein kinases (concentration ≥ 10 μM) including hVps34, PI 3-K downstream kinases, and MAPK family members. Orally available. Induces robust cell cycle arrest at the G1 phase in U87MG cancer cells and antitumor activity in SKOV3 ovarian cancer xenograft models. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 425.48 |
| 分子式 | C22H27N5O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Yuanet al (2011) PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol.Cancer Ther. 10 2189. PMID: 21750219. |
