| 货号 | 2208/50 |
| 别名 | 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6 |
| 供应商 | Tocris |
| 生物活性 | Selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 360.46 |
| 分子式 | C19H28N4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 117690-79-6 |
| 参考文献 | Yokomizoet al (2001) Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J.Biol.Chem. 276 12454. PMID: 11278893. Herronet al (1992) Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. J.Med.Chem. 35 1818. PMID: 1316967. Silbaughet al (1992) Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur.J.Pharmacol. 223 57. PMID: 1335877. |