| 货号 | 2705/50 |
| 别名 | 5-[(3-Chlorophenyl)-1H-imidazol-1-y |
| 供应商 | Tocris |
| 生物活性 | Cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas. |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 381.69 |
| 分子式 | C17H13ClN4.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in water |
| CAS号 | 145858-50-0 |
| 参考文献 | Gosset al (2007) Effects of liarozole fumarate (R85246) in combination with tamoxifen on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model. BMC Cancer 7 26. PMID: 17266767. Njaret al (2006) Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. Bioorg.Med.Chem. 14 4323. PMID: 16530416. Van Wauweet al (1992) Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J.Pharmacol.Exp.Ther. 261 773. PMID: 1374473. |