| 货号 | 1300/50 |
| 别名 | 2-Cyano-N-(2,5-dibromophenyl)-3-hyd |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 360 |
| 分子式 | C11H8Br2N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 62004-35-7 |
| 参考文献 | Crosby and Pool (2002) Interaction of Bruton's tyrosine kinase and protein kinase Cθ in platelets. J.Biol.Chem. 277 9958. PMID: 11788586. Mahajanet al (1999) Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]. J.Biol.Chem. 274 9587. PMID: 10092645. Vassilevet al (1999) Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. J.Biol.Chem. 274 1646. PMID: 9880544. |