| 货号 | 4602/50 |
| 别名 | 2-[(3,4-Dihydro-4-oxo-3,5-diphenylt |
| 供应商 | Tocris |
| 生物活性 | Transglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 408.5 |
| 分子式 | C20H16N4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Primeet al (2012) Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntingtons disease. J.Med.Chem. 55 1021. PMID: 22224594. Case and Stein (2007) Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry 46 1106. PMID: 17240993. Duvalet al (2005) Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg.Med.Chem.Lett. 15 1885. PMID: 15780627. |