| 货号 | 2197/50 |
| 别名 | 4-[[(Hexylamino)carbonyl]amino]-N-[ |
| 供应商 | Tocris |
| 生物活性 | Potentβ3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-,β1- and β2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro(EC50 = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 584.73 |
| 分子式 | C30H40N4O6S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 159182-43-1 |
| 参考文献 | Yuet al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142. PMID: 25658371. Fisheret al (1998) A selective human β3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J.Clin.Invest. 101 2387. PMID: 9616210. Parmeeet al (1998) Discovery of L-755,507: a subnanomolar human β3 adrenergic receptor agonist. Bioorg.Med.Chem.Lett. 8 1107. PMID: 9871717. |