| 货号 | 2760/50 |
| 别名 | N-[[3-[(2S)-2-Hydroxy-3-[[2-[4-[(ph |
| 供应商 | Tocris |
| 生物活性 | Competitiveβ3-adrenoceptor antagonist that displays selectivity over β1andβ2 receptors (Ki values are 4.0, 204 and 390 nM for β3-,β2- and β1-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC50 = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 497.61 |
| 分子式 | C26H31N3O5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 244192-94-7 |
| 参考文献 | Dal Monteet al (2014) β3-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling. Naunyn Schmiedebergs Arch.Pharmacol. 387 533. PMID: 24599317. Neidholdet al (2007) The function of α- and β-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. Br.J.Pharmacol. 150 261. PMID: 17179950. Candeloreet al (1999) Potent and selective human β3-adrenergic receptor antagonist. J.Pharmacol.Exp.Ther. 290 649. PMID: 10411574. |