| 货号 | 4167/50 |
| 别名 | 8-(Hexahydro-2,5-methanopentalen-3a |
| 供应商 | Tocris |
| 生物活性 | Selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 356.46 |
| 分子式 | C20H28N4O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Nishiyamaet al (1999) Adenosine A1 receptor antagonist KW-3902 prevents hypoxia-induced renal vasoconstriction. J.Pharmacol.Exp.Ther. 291 988. PMID: 10565815. Nonakaet al (1996) KW-3902, a selective high affinity antagonist for adenosine A1 receptors. Br.J.Pharmacol. 117 1645. PMID: 8732272. Shimadaet al (1992) 8-polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. J.Med.Chem. 35 924. PMID: 1548682. |