| 货号 | 4351/50 |
| 别名 | (3-endo)-3-[Bis(4-fluorophenyl)meth |
| 供应商 | Tocris |
| 生物活性 | Dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 421.95 |
| 分子式 | C24H29F2NO.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Hiranitaet al (2014 ) Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats. J.Pharmacol.Exp.Ther. 348 174. PMID: 24194527. Kristensenet al (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharm.Rev. 63 (3) 585. Kopajticet al (2010) Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability. J.Pharmacol.Exp.Ther. 335 703. PMID: 20855444. Velaquez-Sanchezet al (2010) The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization. Eur.Neuropsychopharmacol. 20 501. PMID: 20413276. |