| 货号 | 4439/50 |
| 别名 | N-Cyclopropyl-5-(2-thienyl)-3-isoxa |
| 供应商 | Tocris |
| 生物活性 | Neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 234.27 |
| 分子式 | C11H10N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Russellet al (2012) Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem.Biol. 7 1067. PMID: 22413910. Dioumet al (2011) A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713. PMID: 22143803. Zhanget al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233. PMID: 21419563. Schneideret al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408. PMID: 18552832. |