| 货号 | 4016/50 |
| 别名 | Heptanedioic acid-1-(2-cyclopentylidenehydrazide |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro, and gut tube formation in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 240.3 |
| 分子式 | C12H20N2O3 |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 100 mM in DMSO |
| 参考文献 | Filbyet al (2011) Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res.Ther. 2 16. PMID: 21463501. Borowniaket al (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4 348. PMID: 19341624. Zaret (2009) Using small molecules to great effect in stem cell differentiation. Cell Stem Cell 4 373. PMID: 19427285. |