| 货号 | 1322/50 |
| 别名 | 1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl] |
| 供应商 | Tocris |
| 生物活性 | Potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors). Displays > 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 393.5 |
| 分子式 | C19H27N3O4S |
| 可溶性/溶解性 | Soluble to 25 mM in 1eq. HCl |
| CAS号 | 144625-51-4 |
| 参考文献 | Prinset al (2000) An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestinal circular muscle. Br.J.Pharmacol. 129 1601. PMID: 10780964. Van den Wyngaertet al (1997) Cloning and expression of a human serotonin 5-HT4 receptor cDNA. J.Neurochem. 69 1810. PMID: 9349523. Eglenet al (1995) Central 5-HT4 receptors. TiPS 16 391. PMID: 8578609. Galeet al (1994) GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor. Br.J.Pharmacol. 111 332. PMID: 8012715. |