| 货号 | 4427/50 |
| 别名 | 2-[3-Cyano-4-(2-methylpropoxy)pheny |
| 供应商 | Tocris |
| 生物活性 | Non-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 316.37 |
| 分子式 | C16H16N2O3 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Xuet al (2008) Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 14 746. PMID: 18995179. Okamotoet al (2003) An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 278 1848. PMID: 12421831. Osadaet al (1993) Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 241 183. PMID: 8243554. |