| 货号 | 0186/50 |
| 别名 | (±)-1-Aminocyclopentane-cis-1,3-dica |
| 供应商 | Tocris |
| 生物活性 | 1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo. (±)-trans-ACPD (Cat. No. 0187) and (1S,3R)-ACPD (Cat. No. 0284) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 173.17 |
| 分子式 | C7H11NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH |
| 参考文献 | Contiet al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco 57 889. PMID: 12484537. Schoeppet al (1991) In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J.Neurochem. 56 1789. PMID: 1849553. Sunteret al (1991) Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat. Br.J.Pharmacol. 104337P. |