| 货号 | 4567/50 |
| 别名 | 4-[(4-Fluorophenyl)methyl]-2-(4-met |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC50 values are 30.1 nM and 11.0 μM for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 316.35 |
| 分子式 | C16H13FN2O2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Vashisthet al (2013) Conformational dynamics of a regulator of g-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. ACS Chem.Biol. 8 2778. PMID: 24093330. Turneret al (2012) Small molecule inhibitors of regulators of G protein signalling (RGS) proteins. ACS Med.Chem.Lett. 3 146. PMID: 22368763. Blazeret al (2011) A nanomolar potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins. Biochemistry 50 3181. PMID: 21329361. |