| 货号 | 3797/50 |
| 别名 | 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazo |
| 供应商 | Tocris |
| 生物活性 | Putative potassium channel activator; thought to act as a K2P2.1 (TREK-1) channel opener. Exhibits selectivity for bladder over vascular tissue in vitroandin vivo(EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 291.35 |
| 分子式 | C17H17N5 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO |
| 参考文献 | Goncziet al (2006) Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br.J.Pharmacol. 147 496. PMID: 16432512. Tertyshnikovaet al (2005) BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J.Pharmacol.Exp.Ther. 313 250. PMID: 15608074. |