| 货号 | 2316/50 |
| 别名 | (2E)-N-(2,3-Dihydro-1,4-benzodioxin |
| 供应商 | Tocris |
| 生物活性 | Potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 337.42 |
| 分子式 | C21H23NO3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 545395-94-6 |
| 参考文献 | Dohertyet al (2005) Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides. J.Med.Chem. 48 71. PMID: 15634002. Gavvaet al (2005) AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J.Pharmacol.Exp.Ther. 313 474. PMID: 15615864. |