| 货号 | 3507/50 |
| 别名 | 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tet |
| 供应商 | Tocris |
| 生物活性 | Retinoic acid receptor α(RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 351.44 |
| 分子式 | C22H25NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in 1.1eq. NaOH and to 50 mM in DMSO |
| CAS号 | 94497-51-5 |
| 参考文献 | Takenagaet al (2009) The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 32 225. PMID: 19182380. Jimiet al (2007) RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 31 397. PMID: 17611697. Kagechikaet al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182. PMID: 3184125. |