| 货号 | 4033/50 |
| 别名 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene- |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 295.27 |
| 分子式 | C16H10FN3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 861214-33-7 |
| 参考文献 | Choiet al (2010) Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 20 2033. PMID: 20153646. Krivogorskyet al (2008) Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 52 4466. PMID: 18824607. Kimet al (2007) Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 13 253. PMID: 17200363. |