| 货号 | 1124/50 |
| 别名 | (R)-1,4-Dihydro-2,6-dimethyl-4-(3-n |
| 供应商 | Tocris |
| 生物活性 | L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist; less active enantiomer. (S)-(+)-Niguldipine hydrochloride (Cat. No. 1123) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 646.18 |
| 分子式 | C36H39N3O6.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water |
| CAS号 | 113145-70-3 |
| 参考文献 | Wetzelet al (1995) Discovery of alpha1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579. PMID: 7752182. Holltet al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601. PMID: 1352973. Boeret al (1989) (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha1-adrenoceptor. Eur.J.Pharmacol. 172 131. PMID: 2548881. Graziadeiet al (1989) Stereoselective binding of niguldipine enantiomers to alpha1A-adrenoceptors labeled with [3H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329. PMID: 2555206. |