(R)-MG132
货号：
13697-25mg 基本售价：
10542.0 元 规格：
25 mg
产品信息
概述| 货号 | 13697-25mg |
| 描述 | The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression.1,2 (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.3 The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 µM (ChTL); 34.4 versus 104.43 µM (TL); 2.95 versus 5.70 µM (PGPH), respectively).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, D.H. and Goldberg, A.L. Proteasome inhibitors: Valuable new tools for cell biologists. Trends in Cell Biology 8, 397-403 (1998).
2.Elliott, P.J.,Zollner, T.M. and Boehncke, W.H. Proteasome inhibition: A new anti-inflammatory strategy. Journal of Molecular Medicine 81, 235-245 (2003).
3.Mroczkiewicz, M.,Winkler, K.,Nowis, D., et al. Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. Journal of Medicinal Chemistry 53, 1509-1518 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 475.6 |
| 分子式 | C26H41N3O5 |
| CAS号 | 1211877-36-9 |
| 稳定性 | ≥ 2 years |
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