CAY10614
货号：
13615-25mg 基本售价：
10542.0 元 规格：
25 mg
产品信息
概述| 货号 | 13615-25mg |
| 描述 | Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells.1 It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Piazza, M.,Rossini, C.,Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization. Journal of Medicinal Chemistry 52, 1209-1213 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 756 |
| 分子式 | C42H78INO2 |
| CAS号 | 1202208-36-3 |
| 稳定性 | ≥ 2 years |
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