| 货号 | 10532-25mg |
| 描述 | The cysteinyl leukotrienes LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G-protein coupled receptors, CysLT1 and CysLT2.1,2,3BayCysLT2 is a potent CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 35 and >10,000 nM, respectively.4BayCysLT2 concentration-dependently reverses LTC4-stimulated perfusion pressure increase and contractility decrease in isolated Langendorff-perfused guinea pig hearts.4 |
| 别名 | CAY10633; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lynch, K.R.,ONeill, G.P.,Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399, 789-793 (1999). 2.Heise, C.E.,ODowd, B.F.,Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536 (2000). 3.Sarau, H.M.,Ames, R.S.,Chambers, J., et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol. Pharmacol. 56, 657-663 (1999). 4.Harter, M.,Erguden, J.,Wunder, F., et al. Isophtalic acid derivatives. 10/537,623, 1-104 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 589.7 |
| 分子式 | C34H39NO8 |
| CAS号 | 712313-33-2 |
| 稳定性 | ≥ 2 years |
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