GW 590735
货号：
10009880-25mg 基本售价：
10542.0 元 规格：
25 mg
产品信息
概述| 货号 | 10009880-25mg |
| 描述 | The peroxisome proliferator-activated receptors (PPARs) α, γ, and δ are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL.1 GW 590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sierra, M.L.,Beneton, V.,Boullay, A.B., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents. Journal of Medicinal Chemistry 50, 685-695 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 478.5 |
| 分子式 | C23H21F3N2O4S |
| CAS号 | 622402-22-6 |
| 稳定性 | ≥ 2 years |
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