| 货号 | 17694-50mg |
| 描述 | The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes.1 CASIN is an indole-based small molecule that inhibits activation of the Cdc42 GTPase (IC50 = 2 µM for inhibiting actin assembly in PIP2-stimulated actin polymerization assays).2 This compound has been used to explore the role of Cdc42 in the division, survival, and differentiation of hematopoietic stem cells.3,4 |
| 别名 | Pirl1-related Compound 2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bustelo, X.R.,Sauzeau, V., and Berenjeno, I.M. GTP-binding proteins of the Rho/Rac family: Regulation, effectors and functions in vivo. BioEssays 29(4), 356-370 (2007). 2.Peterson, J.R.,Lebensohn, A.M.,Pelish, H.E., et al. Biochemical suppression of small molecule inhibitors: A new strategy to identify inhibitor targets and signaling pathway components. Chemistry & Biology 13(4), 443-452 (2006). 3.Sakamori, R.,Das, S.,Yu, S., et al. Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. Journal of Clinical Investigation 122(3), 1052-1065 (2012). 4.Florian, M.C.,Dörr, K.,Niebel, A., et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 10(5), 520-530 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 306.4 |
| 分子式 | C20H22N2O |
| CAS号 | 425399-05-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |