| 货号 | 2183/50 |
| 别名 | 2-(4-Hydroxyphenyl)-3-methyl-1-[10- |
| 供应商 | Tocris |
| 生物活性 | Potent estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro(IC50 ~ 1 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 513.73 |
| 分子式 | C30H43NO4S |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 177583-70-9 |
| 参考文献 | Walteret al (2004) Synthesis and biological evaluation of stilbene-based pure estrogen antagonists. Bioorg.Med.Chem.Lett. 14 4659. PMID: 15324884. Liuet al (1999) The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system. Biol.Chem. 380 1341. PMID: 10614829. Biberger and von Angerer (1996) 2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumour activity. J.Steroid Biochem.Molec.Biol. 5831. |