| 货号 | 4544/50 |
| 别名 | N-[(3-Aminophenyl)methyl]-6-[4-[(3- |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 516.39 |
| 分子式 | C26H22FN3O3< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Iwamotoet al (2007) Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovasc.Hematol.Disord.Drug Targets 7 188. PMID: 17896959. Iwamoto and Kita (2006) YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol.Pharmacol. 70 2075. PMID: 16973719. |