| 货号 | 3928/50 |
| 别名 | 3-[4-(2,4-Bis-trifluoromethylbenzyl |
| 供应商 | Tocris |
| 生物活性 | Selective ERRα antagonist/inverse agonist (IC50 = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγcoactivator-1α(PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 596.42 |
| 分子式 | C23H13F9N4O3S |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| CAS号 | 725247-18-7 |
| 参考文献 | Konget al (2009) Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Mol.Pharmacol. 76 854. PMID: 19602572. Lanvinet al (2007) Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790. J.Biol.Chem. 282 28328. PMID: 17631492. Willyet al (2004) Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand. Proc.Natl.Acad.Sci.USA 1018912. |