| 货号 | 3748/50 |
| 别名 | 3,5,7,8-Tetrahydro-2-[4-(trifluorom |
| 供应商 | Tocris |
| 生物活性 | Potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 312.31 |
| 分子式 | C14H11F3N2OS |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| CAS号 | 284028-89-3 |
| 参考文献 | Wanget al (2010) Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem. Biol. 6 192. PMID: 21077691. Adler (2009) Inhibiting wnt signaling. Sci.Signal. 91. Huanget al (2009) Tankyrase inhibition stabilizes axin and antagonizes wnt signalling. Nature 461 614. PMID: 19759537. |