| 货号 | 3569/50 |
| 别名 | 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3- |
| 供应商 | Tocris |
| 生物活性 | Functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 371.46 |
| 分子式 | C14H23N3OS.C2H2O4 |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO |
| CAS号 | 141064-23-5 |
| 参考文献 | Heinrichet al (2009) Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur.J.Pharmacol. 605 53. PMID: 19168056. Jakubiket al (2008) Importance and prospects for design of selective muscarinic agonists. Physiol.Res. 57 S39. PMID: 18481916. Stanhopeet al (2001) The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat. J.Pharmacol.Exp.Ther. 299782. |