| 货号 | 3596/50 |
| 别名 | 3,4-Dideoxy-4-[[2-hydroxy-1-(hydrox |
| 供应商 | Tocris |
| 生物活性 | Orally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 267.28 |
| 分子式 | C10H21NO7 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 75 mM in DMSO |
| CAS号 | 83480-29-9 |
| 参考文献 | Matsuiet al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559. PMID: 19359799. Moritohet al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669. PMID: 19208898. Matsuoet al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S. PMID: 1728846. |