| 货号 | 4538/50 |
| 别名 | 2-[(5-Ethyl-1,6-dihydro-4-methyl-6- |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 416.52 |
| 分子式 | C19H20N4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Duvvuriet al (2012) TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. [Epub ahead of print]. PMID: 22564524. Mroz and Keely (2012) Epidermal growth factor chronically upregulates Ca2+-dependent Cl- conductance and TMEM16A expression in intestinal epithelial cells. J.Physiol. 590 1907. PMID: 22351639. Namkunget al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365. PMID: 21084298. |