| 货号 | 3521/50 |
| 别名 | 2-[[(2-Hydroxy-1-naphthalenyl)methy |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 394.47 |
| 分子式 | C26H22N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 410536-97-9 |
| 参考文献 | Jung-Hyneset al (2009) Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 284 3823. PMID: 19075016. Kahyoet al (2008) A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 108 364. PMID: 19008647. Maiet al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789. PMID: 16302818. Grozingeret al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 276 38837. PMID: 11483616. |