| 货号 | 1400/50 |
| 别名 | N-(2,3-Diphenyl-1,2,4-thiadiazol-5( |
| 供应商 | Tocris |
| 生物活性 | Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 348.26 |
| 分子式 | C15H13N3S.HBr |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO with gentle warming |
| CAS号 | 70375-43-8 |
| 参考文献 | Lewandowiczet al (2006) The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 147 422. PMID: 16402041. Gaoet al (2004) Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 74 3173. PMID: 15081581. Fawziet al (2001) SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 59 30. PMID: 11125021. |