| 货号 | 3650/50 |
| 别名 | N-(1-Naphthalenylcarbonyl)-4-nitro- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective CCR3 antagonist (IC50 = 4 nM). Displays > 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca2+ mobilization (IC50 values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 378.38 |
| 分子式 | C21H18N2O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 247580-43-4 |
| 参考文献 | Moriet al (2007) Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int.Immunol. 19 913. PMID: 17804691. Abonyoet al (2005) Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Am.J.Physiol.Lung Cell.Mole.Physiol. 289L478. Whiteet al (2000) Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 275 36626. PMID: 10969084. |